Man United was drawn Friday to face the five-time champions, who beat the storied English club in the 2009 and 2011 finals. Messi scored in each of those matches.
Still, United beat Barcelona in the 2008 semifinals before winning its third title, and it was at Camp Nou that current manager Ole Gunnar Solskjaer scored the stoppage-time winning goal in the 1999 final, against Bayern Munich. Four English teams reached the last eight for the first time in 10 years, and two will meet next month.
Ajax vs Juventus
Tottenham vs Manchester City
Liverpool vs Porto
Barcelona vs Manchester United
Tottenham will host Manchester City in the first leg, which could be played at Wembley Stadium or at the north London club’s soon-to-be-completed new arena. The pairing also brought together the only two teams in the draw who have never been European champion. The other six have won a combined 21 titles. Liverpool will face Porto, a team the five-time champions beat in the last 16 last season. Back then, Liverpool won 5-0 in Portugal to start its route to the final.
Ajax will play Juventus in a rematch of two previous finals. Ajax won in 1973, the third of its four European titles, and Juventus won its second title in 1996.
Last year, Cristiano Ronaldo was bought by Juventus, a team which has lost two finals in the past four years, to end that 23-year wait.
The first legs will be played on April 9-10, with the return games on April 16-17.
The final is scheduled for June 1 at the Metropolitano Stadium, the home of Atletico Madrid.
HOW IT WORKS
Teams will be drawn at random and, unlike previous rounds, teams from the same nation can be pit against each other.
As well as the quarter-final matches, the make-up of the rest of the competition and possible semi-finals will also be determined.
MATCH DATES (AEST)
Quarter-finals Leg 1: April 10 and 11
Quarter-finals Leg 2: April 18 and 18
Semi-finals Leg 1: May 1 and 2
Semi-finals Leg 2: May 8 and 9
Final: June 2 at Estadio Wanda Metropolitano in Madrid, Spain.